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(-) Description

Title :  CRYSTAL STRUCTURE OF ALAMETHICIN AT 1.5 ANGSTROM RESOLUTION
 
Authors :  R. O. Fox, F. M. Richards
Date :  08 Dec 87  (Deposition) - 09 Oct 88  (Release) - 27 Jul 11  (Revision)
Method :  X-RAY DIFFRACTION
Resolution :  1.50
Chains :  Asym./Biol. Unit :  A,B,C
Keywords :  Alamethicin, Peptaibol, Antibacterial, Antifungal, Antibiotic (Keyword Search: [Gene Ontology, PubMed, Web (Google))
 
Reference :  R. O. Fox Jr, F. M. Richards
A Voltage-Gated Ion Channel Model Inferred From The Crystal Structure Of Alamethicin At 1. 5-A Resolution.
Nature V. 300 325 1982
PubMed-ID: 6292726  |  Reference-DOI: 10.1038/300325A0
(for further references see the PDB file header)

(-) Compounds

Molecule 1 - ALAMETHICIN F30
    ChainsA, B, C
    EngineeredYES
    Organism ScientificTRICHODERMA VIRIDE
    Organism Taxid5547
    SynonymALAMETHICIN
    SyntheticYES

 Structural Features

(-) Chains, Units

  123
Asymmetric/Biological Unit ABC

Summary Information (see also Sequences/Alignments below)

(-) Ligands, Modified Residues, Ions  (5, 45)

Asymmetric/Biological Unit (5, 45)
No.NameCountTypeFull Name
1ACE3Mod. Amino AcidACETYL GROUP
2AIB24Mod. Amino AcidALPHA-AMINOISOBUTYRIC ACID
3CCN2Ligand/IonACETONITRILE
4MOH13Ligand/IonMETHANOL
5PHL3Mod. Amino AcidL-PHENYLALANINOL

(-) Sites  (5, 5)

Asymmetric Unit (5, 5)
No.NameEvidenceResiduesDescription
1AC1SOFTWAREALA B:4 , AIB C:5BINDING SITE FOR RESIDUE CCN B 22
2AC2SOFTWAREGLU A:18 , AIB C:17 , PHL C:20BINDING SITE FOR RESIDUE CCN A 22
3AC3SOFTWARECCN A:22 , ACE B:0 , GLN B:7 , GLU B:18 , PRO C:2 , AIB C:3 , GLN C:7 , PHL C:20BINDING SITE FOR CHAIN A OF ALAMETHICIN F30
4AC4SOFTWAREAIB A:1 , AIB A:5 , GLN A:19 , CCN B:22 , ALA C:4 , GLN C:7 , GLY C:11 , LEU C:12 , PRO C:14 , GLU C:18 , GLN C:19 , PHL C:20BINDING SITE FOR CHAIN B OF ALAMETHICIN F30
5AC5SOFTWAREAIB A:1 , ALA A:4 , GLN A:19 , PHL A:20 , CCN A:22 , ACE B:0 , ALA B:6 , GLN B:7 , AIB B:10 , PRO B:14 , VAL B:15 , GLU B:18 , GLN B:19 , CCN B:22BINDING SITE FOR CHAIN C OF ALAMETHICIN F30

(-) SS Bonds  (0, 0)

(no "SS Bond" information available for 1AMT)

(-) Cis Peptide Bonds  (0, 0)

(no "Cis Peptide Bond" information available for 1AMT)

 Sequence-Structure Mapping

(-) SAPs(SNPs)/Variants  (0, 0)

(no "SAP(SNP)/Variant" information available for 1AMT)

(-) PROSITE Motifs  (0, 0)

(no "PROSITE Motif" information available for 1AMT)

(-) Exons   (0, 0)

(no "Exon" information available for 1AMT)

(-) Sequences/Alignments

Asymmetric/Biological Unit
   Reformat: Number of residues per line =  ('0' or empty: single-line sequence representation)
  Number of residues per labelling interval =   
  UniProt sequence: complete  aligned part    
   Show mapping: SCOP domains CATH domains Pfam domains Secondary structure (by author)
SAPs(SNPs) PROSITE motifs Exons
(details for a mapped element are shown in a popup box when the mouse pointer rests over it)
Chain A from PDB  Type:PROTEIN  Length:21
                                                    
               SCOP domains d1amta_ A: Alamecitin SCOP domains
               CATH domains --------------------- CATH domains
               Pfam domains --------------------- Pfam domains
         Sec.struct. author .hhhhhhhhhhhhhhhhhh.. Sec.struct. author
                 SAPs(SNPs) --------------------- SAPs(SNPs)
                    PROSITE --------------------- PROSITE
                 Transcript --------------------- Transcript
                  1amt A  0 xxPxAxAQxVxGLxPVxxEQx 20
                            || | |  |9|  |  ||19|
                            || | |  | |  |  17-AIB
                            0-ACE|  | |  |  |  20-PHL
                             1-AIB  | |  |  |    
                               3-AIB| |  |  |    
                                 5-AIB|  |  |    
                                    8-AIB|  |    
                                     10-AIB |    
                                        13-AIB   
                                           16-AIB

Chain B from PDB  Type:PROTEIN  Length:21
                                                    
               SCOP domains d1amtb_ B: Alamecitin SCOP domains
               CATH domains --------------------- CATH domains
               Pfam domains --------------------- Pfam domains
         Sec.struct. author .hhhhhhhhhhhhhhhhhhhh Sec.struct. author
                 SAPs(SNPs) --------------------- SAPs(SNPs)
                    PROSITE --------------------- PROSITE
                 Transcript --------------------- Transcript
                  1amt B  0 xxPxAxAQxVxGLxPVxxEQx 20
                            || | |  |9|  |  ||19|
                            || | |  | |  |  17-AIB
                            0-ACE|  | |  |  |  20-PHL
                             1-AIB  | |  |  |    
                               3-AIB| |  |  |    
                                 5-AIB|  |  |    
                                    8-AIB|  |    
                                     10-AIB |    
                                        13-AIB   
                                           16-AIB

Chain C from PDB  Type:PROTEIN  Length:21
                                                    
               SCOP domains d1amtc_ C: Alamecitin SCOP domains
               CATH domains --------------------- CATH domains
               Pfam domains --------------------- Pfam domains
         Sec.struct. author .hhhhhhhhhhhhhhhhhhhh Sec.struct. author
                 SAPs(SNPs) --------------------- SAPs(SNPs)
                    PROSITE --------------------- PROSITE
                 Transcript --------------------- Transcript
                  1amt C  0 xxPxAxAQxVxGLxPVxxEQx 20
                            || | |  |9|  |  ||19|
                            || | |  | |  |  17-AIB
                            0-ACE|  | |  |  |  20-PHL
                             1-AIB  | |  |  |    
                               3-AIB| |  |  |    
                                 5-AIB|  |  |    
                                    8-AIB|  |    
                                     10-AIB |    
                                        13-AIB   
                                           16-AIB

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  x → Chemical Group (purple background, 'x', labelled with number + name, e.g. ACE or NH2)
  extra numbering lines below/above indicate numbering irregularities and modified residue names etc., number ends below/above '|'

 Classification and Annotation

(-) SCOP Domains  (1, 3)

Asymmetric/Biological Unit
(-)
Class: Peptides (792)

(-) CATH Domains  (0, 0)

(no "CATH Domain" information available for 1AMT)

(-) Pfam Domains  (0, 0)

(no "Pfam Domain" information available for 1AMT)

(-) Gene Ontology  (0, 0)

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 Related Entries

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(-) Related Entries Specified in the PDB File

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1gq0 SOLUTION STRUCTURE OF THE PEPTAIBOL ANTIAMOEBIN I
1ih9 SOLUTION STRUCTURE OF THE PEPTAIBOL ZERVAMICIN IIB BOUND TO DPC MICELLES
1joh CRYSTAL STRUCTURE OF THE PEPTAIBOL ANTIAMOEBIN I
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1ob4 CRYSTAL STRUCTURE OF THE PEPTAIBOL CEPHAIBOL A
1ob6 CRYSTAL STRUCTURE OF THE PEPTAIBOL CEPHAIBOL B
1ob7 CRYSTAL STRUCTURE OF THE PEPTAIBOL CEPHAIBOL C
1r9u SOLUTION STRUCTURE OF THE PEPTAIBOL ZERVAMICIN IIB IN METHANOL