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(-) Description

Title :  THE STRUCTURE OF ANTIAMOEBIN I, A MEMBRANE-ACTIVE PEPTIDE
 
Authors :  C. F. Snook, B. A. Wallace
Date :  11 Oct 97  (Deposition) - 20 Jan 99  (Release) - 27 Jul 11  (Revision)
Method :  X-RAY DIFFRACTION
Resolution :  1.40
Chains :  Asym. Unit :  A,B
Biol. Unit 1:  A  (1x)
Biol. Unit 2:  B  (1x)
Keywords :  Antiamoebin I, Peptaibol, Antibacterial, Antifungal, Antibiotic (Keyword Search: [Gene Ontology, PubMed, Web (Google))
 
Reference :  C. F. Snook, G. A. Woolley, G. Oliva, V. Pattabhi, S. F. Wood, T. L. Blundell, B. A. Wallace
The Structure And Function Of Antiamoebin I, A Proline-Rich Membrane-Active Polypeptide.
Structure V. 6 783 1998
PubMed-ID: 9655831  |  Reference-DOI: 10.1016/S0969-2126(98)00079-3
(for further references see the PDB file header)

(-) Compounds

Molecule 1 - ANTIAMOEBIN I
    ChainsA, B
    Organism ScientificEMERICELLOPSIS
    Organism Taxid45244

 Structural Features

(-) Chains, Units

  12
Asymmetric Unit AB
Biological Unit 1 (1x)A 
Biological Unit 2 (1x) B

Summary Information (see also Sequences/Alignments below)

(-) Ligands, Modified Residues, Ions  (6, 47)

Asymmetric Unit (6, 47)
No.NameCountTypeFull Name
1ACE2Mod. Amino AcidACETYL GROUP
2AIB12Mod. Amino AcidALPHA-AMINOISOBUTYRIC ACID
3DIV4Mod. Amino AcidD-ISOVALINE
4HYP4Mod. Amino Acid4-HYDROXYPROLINE
5MOH23Ligand/IonMETHANOL
6PHL2Mod. Amino AcidL-PHENYLALANINOL
Biological Unit 1 (6, 23)
No.NameCountTypeFull Name
1ACE1Mod. Amino AcidACETYL GROUP
2AIB6Mod. Amino AcidALPHA-AMINOISOBUTYRIC ACID
3DIV2Mod. Amino AcidD-ISOVALINE
4HYP2Mod. Amino Acid4-HYDROXYPROLINE
5MOH11Ligand/IonMETHANOL
6PHL1Mod. Amino AcidL-PHENYLALANINOL
Biological Unit 2 (6, 24)
No.NameCountTypeFull Name
1ACE1Mod. Amino AcidACETYL GROUP
2AIB6Mod. Amino AcidALPHA-AMINOISOBUTYRIC ACID
3DIV2Mod. Amino AcidD-ISOVALINE
4HYP2Mod. Amino Acid4-HYDROXYPROLINE
5MOH12Ligand/IonMETHANOL
6PHL1Mod. Amino AcidL-PHENYLALANINOL

(-) Sites  (2, 2)

Asymmetric Unit (2, 2)
No.NameEvidenceResiduesDescription
1AC1SOFTWAREPHE B:1 , GLY B:6 , LEU B:7 , AIB B:9 , HYP B:10 , GLN B:11 , PHL B:16BINDING SITE FOR CHAIN A OF ANTIAMOEBIN I
2AC2SOFTWAREDIV A:5 , GLY A:6 , LEU A:7 , AIB A:8 , AIB A:9 , HYP A:10 , GLN A:11 , PHL A:16BINDING SITE FOR CHAIN B OF ANTIAMOEBIN I

(-) SS Bonds  (0, 0)

(no "SS Bond" information available for 1JOH)

(-) Cis Peptide Bonds  (0, 0)

(no "Cis Peptide Bond" information available for 1JOH)

 Sequence-Structure Mapping

(-) SAPs(SNPs)/Variants  (0, 0)

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(-) PROSITE Motifs  (0, 0)

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(-) Exons   (0, 0)

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(-) Sequences/Alignments

Asymmetric Unit
   Reformat: Number of residues per line =  ('0' or empty: single-line sequence representation)
  Number of residues per labelling interval =   
  UniProt sequence: complete  aligned part    
   Show mapping: SCOP domains CATH domains Pfam domains Secondary structure (by author)
SAPs(SNPs) PROSITE motifs Exons
(details for a mapped element are shown in a popup box when the mouse pointer rests over it)
Chain A from PDB  Type:PROTEIN  Length:17
                                                
               SCOP domains ----------------- SCOP domains
               CATH domains ----------------- CATH domains
               Pfam domains ----------------- Pfam domains
         Sec.struct. author .hhhhhhhhhh...... Sec.struct. author
                 SAPs(SNPs) ----------------- SAPs(SNPs)
                    PROSITE ----------------- PROSITE
                 Transcript ----------------- Transcript
                  1joh A  0 xFxxxxGLxxpQxpxPx 16
                            | ||||  |9| ||| |
                            | ||||  ||| 13-HYP
                            0-ACE|  ||| |14-AIB
                              2-AIB ||| |  16-PHL
                               3-AIB||| |    
                                4-AIB|| |    
                                 5-DIV| |    
                                    8-AIB    
                                     9-AIB   
                                     10-HYP  

Chain B from PDB  Type:PROTEIN  Length:17
                                                
               SCOP domains ----------------- SCOP domains
               CATH domains ----------------- CATH domains
               Pfam domains ----------------- Pfam domains
         Sec.struct. author ..hhhhhhhhh...... Sec.struct. author
                 SAPs(SNPs) ----------------- SAPs(SNPs)
                    PROSITE ----------------- PROSITE
                 Transcript ----------------- Transcript
                  1joh B  0 xFxxxxGLxxpQxpxPx 16
                            | ||||  |9| ||| |
                            | ||||  ||| 13-HYP
                            0-ACE|  ||| |14-AIB
                              2-AIB ||| |  16-PHL
                               3-AIB||| |    
                                4-AIB|| |    
                                 5-DIV| |    
                                    8-AIB    
                                     9-AIB   
                                     10-HYP  

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  extra numbering lines below/above indicate numbering irregularities and modified residue names etc., number ends below/above '|'

 Classification and Annotation

(-) SCOP Domains  (0, 0)

(no "SCOP Domain" information available for 1JOH)

(-) CATH Domains  (0, 0)

(no "CATH Domain" information available for 1JOH)

(-) Pfam Domains  (0, 0)

(no "Pfam Domain" information available for 1JOH)

(-) Gene Ontology  (0, 0)

Asymmetric Unit(hide GO term definitions)
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 Related Entries

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(-) Related Entries Specified in the PDB File

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1gq0 SOLUTION STRUCTURE OF THE PEPTAIBOL ANTIAMOEBIN I
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1m24 CRYSTAL STRUCTURE OF THE PEPTAIBOL TRICHOTOXIN_A50E
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1ob6 CRYSTAL STRUCTURE OF THE PEPTAIBOL CEPHAIBOL B
1ob7 CRYSTAL STRUCTURE OF THE PEPTAIBOL CEPHAIBOL C
1r9u SOLUTION STRUCTURE OF THE PEPTAIBOL ZERVAMICIN IIB IN METHANOL