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(-) Description

Title :  SOLUTION STRUCTURE OF THE SECOND SH3 DOMAIN OF HUMAN KIAA0769 PROTEIN
 
Authors :  X. R. Qin, C. Kurosaki, M. Yoshida, F. Hayashi, S. Yokoyama, Riken Structural Genomics/Proteomics Initiative (Rsgi)
Date :  17 Apr 06  (Deposition) - 17 Oct 06  (Release) - 24 Feb 09  (Revision)
Method :  SOLUTION NMR
Resolution :  NOT APPLICABLE
Chains :  NMR Structure  :  A  (20x)
Keywords :  Sh3 Domain, Kiaa0769, Fchsd2, Structural Genomics, Nppsfa, National Project On Protein Structural And Functional Analyses, Riken Structural Genomics/Proteomics Initiative, Rsgi, Unknown Function (Keyword Search: [Gene Ontology, PubMed, Web (Google)] )
 
Reference :  X. R. Qin, C. Kurosaki, M. Yoshida, F. Hayashi, S. Yokoyama
Solution Structure Of The Second Sh3 Domain Of Human Kiaa0769 Protein
To Be Published
PubMed: search
(for further references see the PDB file header)

(-) Compounds

Molecule 1 - KIAA0769 PROTEIN
    Chains: A
    Engineered: YES
    Expression System: CELL FREE SYNTHESIS
    Expression System Plasmid: P050725-12
    Expression System Vector Type: PLASMID
    Fragment: SH3 DOMAIN
    Gene: FCHSD2, KIAA0769
    Organism Common: HUMAN
    Organism Scientific: HOMO SAPIENS
    Organism Taxid: 9606
    Other Details: CELL FREE PROTEIN SYNTHESIS

 Structural Features

(-) Chains, Units

  
NMR Structure (20x): 

Summary Information (see also Sequences/Alignments below)

(-) Ligands, Modified Residues, Ions  (0, 0)

(no "Ligand,Modified Residues,Ions" information available for 2DL7)

(-) Sites  (0, 0)

(no "Site" information available for 2DL7)

(-) SS Bonds  (0, 0)

(no "SS Bond" information available for 2DL7)

(-) Cis Peptide Bonds  (0, 0)

(no "Cis Peptide Bond" information available for 2DL7)

 Sequence-Structure Mapping

(-) SAPs(SNPs)/Variants  (0, 0)

(no "SAP(SNP)/Variant" information available for 2DL7)

(-) PROSITE Motifs  (1, 1)

NMR Structure (1, 1)
 PROSITEUniProtKBPDB
No.IDACDescriptionIDLocationCountLocation
1SH3PS50002 Src homology 3 (SH3) domain profile.FCSD2_HUMAN469-530
567-629		  1-
A:8-67

(-) Exons   (0, 0)

(no "Exon" information available for 2DL7)

(-) Sequences/Alignments

NMR Structure
   Reformat: Number of residues per line =  ('0' or empty: single-line sequence representation)
  Number of residues per labelling interval =   
  UniProt sequence: complete  aligned part    
   Show mapping: SCOP domains CATH domains Pfam domains Secondary structure (by author)
SAPs(SNPs) PROSITE motifs Exons
(details for a mapped element are shown in a popup box when the mouse pointer rests over it) 
Chain A from PDB  Type:PROTEIN  Length:73
 aligned with FCSD2_HUMAN | O94868 from UniProtKB/Swiss-Prot  Length:740

    Alignment length:106
                                   570       580       590       600       610       620       630       640       650       660      
          FCSD2_HUMAN   561 GSLNGDASVCFVKALYDYEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFPSVLVEELSASENGDTPWMREIQISPSPKPHASLPPLPLYDQPPSSP 666
               SCOP domains d2 dl7a_ A: automated matches                                                                              SCOP domains
               CATH domains ---------------------------------------------------------------------------------------------------------- CATH domains
               Pfam domains ---------------------------------------------------------------------------------------------------------- Pfam domains
         Sec.struct. author ..-......eeeee..................eeeeee.........eeeee..eeeee....eee...---.-----------------------------.... Sec.struct. author
                 SAPs(SNPs) ---------------------------------------------------------------------------------------------------------- SAPs(SNPs)
                    PROSITE ------SH3  PDB: A:8-67 UniProt: 567-629                              ------------------------------------- PROSITE
                 Transcript ---------------------------------------------------------------------------------------------------------- Transcript
                 2dl7 A   1 GS-SGSSGVCFVKALYDYEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFPSVLVEELSS---G-----------------------------PSSG  73
                             | |     9        19        29        39        49        59        |-  |      -         -         -  |   
                             2 3                                                               68  69                            70
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  extra numbering lines below/above indicate numbering irregularities and modified residue names etc., number ends below/above '|'

 Classification and Annotation

(-) SCOP Domains  (1, 1)

NMR Structure
(-)
Class: All beta proteins (24004)

(-) CATH Domains  (0, 0)

(no "CATH Domain" information available for 2DL7)

(-) Pfam Domains  (0, 0)

(no "Pfam Domain" information available for 2DL7)

(-) Gene Ontology  (1, 1)

NMR Structure(hide GO term definitions)
Chain A   (FCSD2_HUMAN | O94868)
molecular function
    GO:0005515    protein binding    Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

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 Related Entries

(-) Entries Sharing at Least One Protein Chain (UniProt ID)

UniProtKB/Swiss-Prot
        FCSD2_HUMAN | O94868: 2dl5

(-) Related Entries Specified in the PDB File

2dl5 SAME PROTEIN RELATED ID: HSK002100751.1 RELATED DB: TARGETDB