| molecular function |
|---|
| | GO:0005524 | | ATP binding | | Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| | GO:0003723 | | RNA binding | | Interacting selectively and non-covalently with an RNA molecule or a portion thereof. |
| | GO:0003968 | | RNA-directed 5'-3' RNA polymerase activity | | Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. |
| | GO:0004197 | | cysteine-type endopeptidase activity | | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. |
| | GO:0008234 | | cysteine-type peptidase activity | | Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. |
| | GO:0004519 | | endonuclease activity | | Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. |
| | GO:0004527 | | exonuclease activity | | Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. |
| | GO:0016896 | | exoribonuclease activity, producing 5'-phosphomonoesters | | Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters. |
| | GO:0004386 | | helicase activity | | Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix. |
| | GO:0016787 | | hydrolase activity | | Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. |
| | GO:0046872 | | metal ion binding | | Interacting selectively and non-covalently with any metal ion. |
| | GO:0008168 | | methyltransferase activity | | Catalysis of the transfer of a methyl group to an acceptor molecule. |
| | GO:0004518 | | nuclease activity | | Catalysis of the hydrolysis of ester linkages within nucleic acids. |
| | GO:0000166 | | nucleotide binding | | Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. |
| | GO:0016779 | | nucleotidyltransferase activity | | Catalysis of the transfer of a nucleotidyl group to a reactant. |
| | GO:0008242 | | omega peptidase activity | | Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups). |
| | GO:0008233 | | peptidase activity | | Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. |
| | GO:0036459 | | thiol-dependent ubiquitinyl hydrolase activity | | Catalysis of the thiol-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin. |
| | GO:0016740 | | transferase activity | | Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. |
| | GO:0008270 | | zinc ion binding | | Interacting selectively and non-covalently with zinc (Zn) ions. |
| biological process |
|---|
| | GO:0090503 | | RNA phosphodiester bond hydrolysis, exonucleolytic | | The chemical reactions and pathways involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides. |
| | GO:0030683 | | evasion or tolerance by virus of host immune response | | Any process, either active or passive, by which a virus avoids the effects of the host organism's immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction. |
| | GO:0039520 | | induction by virus of host autophagy | | Any process in which a virus activates or increases the frequency, rate or extent of autophagy in the host. |
| | GO:0032259 | | methylation | | The process in which a methyl group is covalently attached to a molecule. |
| | GO:0039648 | | modulation by virus of host protein ubiquitination | | Any process in which a virus modulates the frequency, rate or extent of protein ubiquitination in the host organism. Ubiquitination is the process in which one or more ubiquitin groups are added to a protein. |
| | GO:0090305 | | nucleic acid phosphodiester bond hydrolysis | | The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis. |
| | GO:0006508 | | proteolysis | | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
| | GO:0039548 | | suppression by virus of host IRF3 activity | | Any process in which a virus stops, prevents, or reduces the activity of host IRF3 (interferon regulatory factor-3), a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF3, which allows IRF3 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes. |
| | GO:0039503 | | suppression by virus of host innate immune response | | Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the innate immune response of the host organism, the host's first line of defense. |
| | GO:0006351 | | transcription, DNA-templated | | The cellular synthesis of RNA on a template of DNA. |
| | GO:0001172 | | transcription, RNA-templated | | The cellular synthesis of RNA on a template of RNA. |
| | GO:0039694 | | viral RNA genome replication | | The replication of a viral RNA genome. |
| | GO:0019079 | | viral genome replication | | Any process involved directly in viral genome replication, including viral nucleotide metabolism. |
| | GO:0016032 | | viral process | | A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle. |
| | GO:0019082 | | viral protein processing | | Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a viral protein. |
| cellular component |
|---|
| | GO:0030430 | | host cell cytoplasm | | The cytoplasm of a host cell. |
| | GO:0044172 | | host cell endoplasmic reticulum-Golgi intermediate compartment | | A complex system of membrane-bounded compartments located between host cell endoplasmic reticulum (ER) and the host Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi transport. |
| | GO:0033644 | | host cell membrane | | Double layer of lipid molecules as it encloses host cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. The host is defined as the larger of the organisms involved in a symbiotic interaction. |
| | GO:0044220 | | host cell perinuclear region of cytoplasm | | The host cell cytoplasm situated near, or occurring around, the host nucleus. |
| | GO:0016021 | | integral component of membrane | | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| | GO:0016020 | | membrane | | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
Description
