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(-) Description

Title :  C1S CUB2-CCP1
 
Authors :  R. Wallis, U. Venkatraman Girija, P. C. E. Moody, J. E. Marshall, A. R. G
Date :  13 Jul 13  (Deposition) - 07 Aug 13  (Release) - 04 Sep 13  (Revision)
Method :  X-RAY DIFFRACTION
Resolution :  2.00
Chains :  Asym./Biol. Unit :  A
Keywords :  Cub Domain, Ccp Domain, Complement C1S, Hydrolase (Keyword Search: [Gene Ontology, PubMed, Web (Google))
 
Reference :  U. Venkatraman Girija, A. R. Gingras, J. E. Marshall, R. Panchal, M. A. Sheikh, P. Gal, W. J. Schwaeble, D. A. Mitchell, P. C. Moody, R. Wallis
Structural Basis Of The C1Q/C1S Interaction And Its Central Role In Assembly Of The C1 Complex Of Complement Activation
Proc. Natl. Acad. Sci. Usa V. 110 13916 2013
PubMed-ID: 23922389  |  Reference-DOI: 10.1073/PNAS.1311113110

(-) Compounds

Molecule 1 - COMPLEMENT C1S SUBCOMPONENT HEAVY CHAIN
    ChainsA
    EC Number3.4.21.42
    EngineeredYES
    Expression SystemESCHERICHIA COLI
    Expression System Taxid562
    FragmentCUB2-CCP1 FRAGMENT (UNP RESIDUES 172-358)
    GeneC1S
    Organism CommonHUMAN
    Organism ScientificHOMO SAPIENS
    Organism Taxid9606
    SynonymC1 ESTERASE, COMPLEMENT COMPONENT 1 SUBCOMPONENT S

 Structural Features

(-) Chains, Units

  1
Asymmetric/Biological Unit A

Summary Information (see also Sequences/Alignments below)

(-) Ligands, Modified Residues, Ions  (1, 1)

Asymmetric/Biological Unit (1, 1)
No.NameCountTypeFull Name
1CA1Ligand/IonCALCIUM ION

(-) Sites  (1, 1)

Asymmetric Unit (1, 1)
No.NameEvidenceResiduesDescription
1AC1SOFTWAREGLU A:211 , ASP A:221 , ASP A:260 , THR A:262 , GLY A:263 , HOH A:501BINDING SITE FOR RESIDUE CA A 401

(-) SS Bonds  (4, 4)

Asymmetric/Biological Unit
No.Residues
1A:160 -A:187
2A:219 -A:236
3A:279 -A:326
4A:306 -A:339

(-) Cis Peptide Bonds  (3, 3)

Asymmetric/Biological Unit
No.Residues
1Tyr A:177 -Pro A:178
2Gly A:233 -Pro A:234
3Glu A:290 -Pro A:291

 Sequence-Structure Mapping

(-) SAPs(SNPs)/Variants  (0, 0)

(no "SAP(SNP)/Variant" information available for 4LOS)

(-) PROSITE Motifs  (0, 0)

(no "PROSITE Motif" information available for 4LOS)

(-) Exons   (0, 0)

(no "Exon" information available for 4LOS)

(-) Sequences/Alignments

Asymmetric/Biological Unit
   Reformat: Number of residues per line =  ('0' or empty: single-line sequence representation)
  Number of residues per labelling interval =   
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SAPs(SNPs) PROSITE motifs Exons
(details for a mapped element are shown in a popup box when the mouse pointer rests over it)
Chain A from PDB  Type:PROTEIN  Length:187
                                                                                                                                                                                                                           
               SCOP domains ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SCOP domains
               CATH domains ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- CATH domains
               Pfam domains ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pfam domains
         Sec.struct. author ....eeeee...eeeee............eeeeeee....eeeeee.hhh.eee...........eeeeee..eeeeee.ee......eee....eeeeeee........eeeeeeeeee..........eeee..........eeeeee...eeee.......eeeee............eeee.. Sec.struct. author
                 SAPs(SNPs) ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SAPs(SNPs)
                    PROSITE ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PROSITE
                 Transcript ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Transcript
                 4los A 157 GVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVD 343
                                   166       176       186       196       206       216       226       236       246       256       266       276       286       296       306       316       326       336       

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  extra numbering lines below/above indicate numbering irregularities and modified residue names etc., number ends below/above '|'

 Classification and Annotation

(-) SCOP Domains  (0, 0)

(no "SCOP Domain" information available for 4LOS)

(-) CATH Domains  (0, 0)

(no "CATH Domain" information available for 4LOS)

(-) Pfam Domains  (0, 0)

(no "Pfam Domain" information available for 4LOS)

(-) Gene Ontology  (16, 16)

Asymmetric/Biological Unit(hide GO term definitions)

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 Related Entries

(-) Entries Sharing at Least One Protein Chain (UniProt ID)

UniProtKB/Swiss-Prot
        C1S_HUMAN | P098711elv 1nzi 4j1y 4lmf 4lor 4lot

(-) Related Entries Specified in the PDB File

4lmf 4los 4lot