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(-) Description

Title :  CRYSTAL STRUCTURE OF THE ADENOSINE KINASE FROM MUS MUSCULUS IN COMPLEX WITH ADENOSINE AND ADENOSINE-DIPHOSPHATE
 
Authors :  R. R. Oliveira, R. M. Neto, C. C. Polo, C. C. C. Tonoli, M. T. Murakami, K. G. Franchini
Date :  02 Jun 16  (Deposition) - 07 Jun 17  (Release) - 14 Jun 17  (Revision)
Method :  X-RAY DIFFRACTION
Resolution :  1.80
Chains :  Asym./Biol. Unit :  A
Keywords :  Adenosine Kinase, Transferase (Keyword Search: [Gene Ontology, PubMed, Web (Google)] )
 
Reference :  R. R. Oliveira, R. M. Neto, C. C. Polo, C. C. C. Tonoli, M. T. Murakami, K. G. Franchini
Crystal Structure Of The Adenosine Kinase From Mus Musculus In Complex With Adenosine And Adenosine-Diphosphate
To Be Published
PubMed: search

(-) Compounds

Molecule 1 - ADENOSINE KINASE
    Chains: A
    EC Number: 2.7.1.20
    Engineered: YES
    Expression System: ESCHERICHIA COLI
    Expression System Taxid: 562
    Gene: ADK
    Organism Common: MOUSE
    Organism Scientific: MUS MUSCULUS
    Organism Taxid: 10090
    Synonym: AK,ADENOSINE 5'-PHOSPHOTRANSFERASE

 Structural Features

(-) Chains, Units

  1
Asymmetric/Biological Unit : A

Summary Information (see also Sequences/Alignments below)

(-) Ligands, Modified Residues, Ions  (7, 10)

Asymmetric/Biological Unit (7, 10)
No.NameCountTypeFull Name
1ADN1Ligand/IonADENOSINE
2ADP1Ligand/IonADENOSINE-5'-DIPHOSPHATE
3CL1Ligand/IonCHLORIDE ION
4K1Ligand/IonPOTASSIUM ION
5MG2Ligand/IonMAGNESIUM ION
6PG42Ligand/IonTETRAETHYLENE GLYCOL
7PO42Ligand/IonPHOSPHATE ION

(-) Sites  (10, 10)

Asymmetric Unit (10, 10)
No.NameEvidenceResiduesDescription
01AC1SOFTWAREASN A:30 , LEU A:32 , ASP A:34 , GLY A:79 , GLY A:80 , SER A:81 , ASN A:84 , CYS A:139 , ALA A:152 , PHE A:186 , ASN A:312 , GLY A:313 , ASP A:316 , CL A:404 , HOH A:563 , HOH A:567 , HOH A:585 , HOH A:607binding site for residue ADN A 401
02AC2SOFTWAREARG A:148 , ASN A:239 , THR A:281 , GLN A:282 , GLY A:283 , ARG A:284 , THR A:287 , ASP A:302 , GLN A:305 , ILE A:308 , ALA A:314 , GLY A:315 , HIS A:340 , ALA A:343 , MG A:405 , MG A:406 , HOH A:512 , HOH A:518 , HOH A:521 , HOH A:522 , HOH A:527 , HOH A:535 , HOH A:538 , HOH A:554 , HOH A:563 , HOH A:568 , HOH A:616binding site for residue ADP A 402
03AC3SOFTWAREASP A:310 , ASN A:312 , ILE A:346 , ARG A:349 , GLY A:351binding site for residue K A 403
04AC4SOFTWAREGLY A:29 , ASN A:30 , THR A:82 , ADN A:401binding site for residue CL A 404
05AC5SOFTWAREADP A:402 , HOH A:514 , HOH A:517 , HOH A:554 , HOH A:555binding site for residue MG A 405
06AC6SOFTWAREADP A:402 , HOH A:522 , HOH A:534 , HOH A:538 , HOH A:568binding site for residue MG A 406
07AC7SOFTWAREHIS A:97 , ALA A:120 , HIS A:123 , GLU A:356binding site for residue PG4 A 407
08AC8SOFTWARELEU A:168 , ASP A:256 , LYS A:262 , ASP A:294 , VAL A:295 , HOH A:589binding site for residue PG4 A 408
09AC9SOFTWAREHIS A:127 , ARG A:170 , LYS A:258 , HOH A:544binding site for residue PO4 A 409
10AD1SOFTWAREHIS A:77 , LYS A:118 , THR A:353 , HOH A:509 , HOH A:587 , HOH A:600binding site for residue PO4 A 410

(-) SS Bonds  (0, 0)

(no "SS Bond" information available for 5KB5)

(-) Cis Peptide Bonds  (1, 1)

Asymmetric/Biological Unit
No.Residues
1Glu A:95 -Pro A:96

 Sequence-Structure Mapping

(-) SAPs(SNPs)/Variants  (0, 0)

(no "SAP(SNP)/Variant" information available for 5KB5)

(-) PROSITE Motifs  (0, 0)

(no "PROSITE Motif" information available for 5KB5)

(-) Exons   (0, 0)

(no "Exon" information available for 5KB5)

(-) Sequences/Alignments

Asymmetric/Biological Unit
   Reformat: Number of residues per line =  ('0' or empty: single-line sequence representation)
  Number of residues per labelling interval =   
  UniProt sequence: complete  aligned part    
   Show mapping: SCOP domains CATH domains Pfam domains Secondary structure (by author)
SAPs(SNPs) PROSITE motifs Exons
(details for a mapped element are shown in a popup box when the mouse pointer rests over it) 
Chain A from PDB  Type:PROTEIN  Length:341
                                                                                                                                                                                                                                                                                                                                                                                     
               SCOP domains ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SCOP domains
               CATH domains ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- CATH domains
               Pfam domains ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Pfam domains
         Sec.struct. author .....eeee...eeeeeee.hhhhhhhh.....eeee.hhhhhhhhhhhhhhh..eeeeehhhhhhhhhhhhhhh.....eeeeeeee.hhhhhhhhhhhhhh..eeeeeee.....eeeeeeee..eeeeeeehhhhhhhhhhhh..hhhhhhhhhhh.eeeee.hhhhhhhhhhhhhhhhhhhh..eeeee..hhhhhhhhhhhhhhhhhhh.eeeeehhhhhhhhhhh.....hhhhhhhhhhh..........eeeeee..eeeeeee..eeeee.....hhhhh....hhhhhhhhhhhhhhh...hhhhhhhhhhhhhhhhh............. Sec.struct. author
                 SAPs(SNPs) ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SAPs(SNPs)
                    PROSITE ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PROSITE
                 Transcript ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Transcript
                 5kb5 A  20 LSENVLFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSMKVAQWLIQEPHKAATFFGCIGIDKFGEILKRKAADAHVDAHYYEQNEQPTGTCAACITGGNRSLVANLAAANCYKKEKHLDLERNWVLVEKARVYYIAGFFLTVSPESVLKVARYAAENNRVFTLNLSAPFISQFFKEALMDVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKAQALPKVNSKRQRTVIFTQGRDDTIVAAENDVTAFPVLDQNQEEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASVIIRRTGCTFPEKPDF 360
                                    29        39        49        59        69        79        89        99       109       119       129       139       149       159       169       179       189       199       209       219       229       239       249       259       269       279       289       299       309       319       329       339       349       359
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  extra numbering lines below/above indicate numbering irregularities and modified residue names etc., number ends below/above '|'

 Classification and Annotation

(-) SCOP Domains  (0, 0)

(no "SCOP Domain" information available for 5KB5)

(-) CATH Domains  (0, 0)

(no "CATH Domain" information available for 5KB5)

(-) Pfam Domains  (0, 0)

(no "Pfam Domain" information available for 5KB5)

(-) Gene Ontology  (21, 21)

Asymmetric/Biological Unit(hide GO term definitions)

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        ADK_MOUSE | P55264: 5kb6

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5kb6