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(-) Description

Title :  CRYSTAL STRUCTURE OF THE REDUCED STATE OF THE THIOL-DISULFIDE REDUCTASE SDBA FROM STREPTOCOCCUS GORDONII
 
Authors :  P. J. Stogios, E. Evdokimova, Z. Wawrzak, V. Yim, A. Savchenko, W. F. And Center For Structural Genomics Of Infectious Diseases (Csgi
Date :  26 Jan 17  (Deposition) - 15 Feb 17  (Release) - 15 Feb 17  (Revision)
Method :  X-RAY DIFFRACTION
Resolution :  1.62
Chains :  Asym. Unit :  A,B
Biol. Unit 1:  A  (1x)
Biol. Unit 2:  B  (1x)
Keywords :  Thioredoxin-Like Domain, Alpha-Beta Protein, Oxidoreductase, Structural Genomics, Center For Structural Genomics Of Infectious Diseases, Csgid, National Institute Of Allergy And Infectious Diseases, Niaid (Keyword Search: [Gene Ontology, PubMed, Web (Google))
 
Reference :  P. J. Stogios
To Be Published
To Be Published
PubMed: search

(-) Compounds

Molecule 1 - THIOREDOXIN SIGNATURE PROTEIN
    ChainsA, B
    EngineeredYES
    Expression SystemESCHERICHIA COLI
    Expression System PlasmidPMCSG53
    Expression System StrainBL21(DE3)GOLD
    Expression System Taxid469008
    Expression System Vector TypePLASMID
    GeneSGO_2006
    Organism ScientificSTREPTOCOCCUS GORDONII (STRAIN CHALLIS / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288)
    Organism Taxid467705
    StrainCHALLIS / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288

 Structural Features

(-) Chains, Units

  12
Asymmetric Unit AB
Biological Unit 1 (1x)A 
Biological Unit 2 (1x) B

Summary Information (see also Sequences/Alignments below)

(-) Ligands, Modified Residues, Ions  (1, 1)

Asymmetric Unit (1, 1)
No.NameCountTypeFull Name
1ACT1Ligand/IonACETATE ION
Biological Unit 1 (1, 1)
No.NameCountTypeFull Name
1ACT1Ligand/IonACETATE ION
Biological Unit 2 (0, 0)
No.NameCountTypeFull Name
1ACT-1Ligand/IonACETATE ION

(-) Sites  (1, 1)

Asymmetric Unit (1, 1)
No.NameEvidenceResiduesDescription
1AC1SOFTWAREHIS A:5 , GLU A:6 , LEU A:7 , LEU A:108 , HIS A:109 , TYR A:117 , HOH A:331binding site for residue ACT A 201

(-) SS Bonds  (0, 0)

(no "SS Bond" information available for 5UM7)

(-) Cis Peptide Bonds  (2, 2)

Asymmetric Unit
No.Residues
1Asp A:74 -Ser A:75
2Ile A:113 -Pro A:114

 Sequence-Structure Mapping

(-) SAPs(SNPs)/Variants  (0, 0)

(no "SAP(SNP)/Variant" information available for 5UM7)

(-) PROSITE Motifs  (0, 0)

(no "PROSITE Motif" information available for 5UM7)

(-) Exons   (0, 0)

(no "Exon" information available for 5UM7)

(-) Sequences/Alignments

Asymmetric Unit
   Reformat: Number of residues per line =  ('0' or empty: single-line sequence representation)
  Number of residues per labelling interval =   
  UniProt sequence: complete  aligned part    
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SAPs(SNPs) PROSITE motifs Exons
(details for a mapped element are shown in a popup box when the mouse pointer rests over it)
Chain A from PDB  Type:PROTEIN  Length:140
                                                                                                                                                                            
               SCOP domains -------------------------------------------------------------------------------------------------------------------------------------------- SCOP domains
               CATH domains -------------------------------------------------------------------------------------------------------------------------------------------- CATH domains
               Pfam domains -------------------------------------------------------------------------------------------------------------------------------------------- Pfam domains
         Sec.struct. author .....ee....eee.....eee........eeeeee...hhhhhhhhhhhhhhhhhhh.....eeeee......hhhhhhhhhhhh........hhhhhhhhhhh.....eeeee....eeeeee....hhhhhhhhhhh Sec.struct. author
                 SAPs(SNPs) -------------------------------------------------------------------------------------------------------------------------------------------- SAPs(SNPs)
                    PROSITE -------------------------------------------------------------------------------------------------------------------------------------------- PROSITE
                 Transcript -------------------------------------------------------------------------------------------------------------------------------------------- Transcript
                 5um7 A   5 HELTGQQLPEFEMVDQAGYQKKSAEFYNKPMLVVEWASWCPDCQKQLPEIQKVYEKYKGKIHFVMLDMLDSKRETKERADQYISEKDYTFPYYYDTDERAADILHVQSIPTIYLVDKNQKVKKVMTDFHDEAALEKQLEE 144
                                    14        24        34        44        54        64        74        84        94       104       114       124       134       144

Chain B from PDB  Type:PROTEIN  Length:142
                                                                                                                                                                              
               SCOP domains ---------------------------------------------------------------------------------------------------------------------------------------------- SCOP domains
               CATH domains ---------------------------------------------------------------------------------------------------------------------------------------------- CATH domains
               Pfam domains ---------------------------------------------------------------------------------------------------------------------------------------------- Pfam domains
         Sec.struct. author ............eee.....eee........eeeeee...hhhhhhhhhhhhhhhhhhh....eeeeeee.....hhhhhhhhhhhhh....eeee..hhhhhhh.......eeee.....eeeee....hhhhhhhhhhh. Sec.struct. author
                 SAPs(SNPs) ---------------------------------------------------------------------------------------------------------------------------------------------- SAPs(SNPs)
                    PROSITE ---------------------------------------------------------------------------------------------------------------------------------------------- PROSITE
                 Transcript ---------------------------------------------------------------------------------------------------------------------------------------------- Transcript
                 5um7 B   4 EHELTGQQLPEFEMVDQAGYQKKSAEFYNKPMLVVEWASWCPDCQKQLPEIQKVYEKYKGKIHFVMLDMLDSKRETKERADQYISEKDYTFPYYYDTDERAADILHVQSIPTIYLVDKNQKVKKVMTDFHDEAALEKQLEEI 145
                                    13        23        33        43        53        63        73        83        93       103       113       123       133       143  

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  extra numbering lines below/above indicate numbering irregularities and modified residue names etc., number ends below/above '|'

 Classification and Annotation

(-) SCOP Domains  (0, 0)

(no "SCOP Domain" information available for 5UM7)

(-) CATH Domains  (0, 0)

(no "CATH Domain" information available for 5UM7)

(-) Pfam Domains  (0, 0)

(no "Pfam Domain" information available for 5UM7)

(-) Gene Ontology  (6, 6)

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