	Entries with manually generated images from the JenaLib are marked in bold. The structural information is taken from the first listed PDB/NDB entry. All sites can be visualized interactively (RasMol/Chime/VRML) on the JenaLib atlas pages.

From the Database of Sites

Structures with the requested type and number of components in the site: e.g. [ ... MTX(2) ... ].

70 entries selected from siteDir WHERE ucase(siteDir.Residue) RLIKE '.* MTX .*'

Note, that sites with one and the same site ID may differ and that different site IDs may describe related (homologous) sites. The frequency of occurrence of a particular site component is given in parentheses. Clicking on the identifier e.g. CAT describing a particular site starts a RasMol/Chime visualization. Rendering: Thick sticks or CPK - site component e.g. CAT

AC1

Code	Class Resolution	Description
1axw	prot     1.70	 AC1 [ ARG(4) ASN(1) ASP(1) CYS(2) GLN(1) HIS(2) HOH(2) MTX(1) SER(1) TYR(1) ]	E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH METHOTREXATE (MTX) AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) THYMIDYLATE SYNTHASE METHYLTRANSFERASE METHYLTRANSFERASE, TRANSFERASE, INHIBITOR
1d1g	prot     2.10	 AC1 [ ALA(2) ARG(3) GLU(2) GLY(4) HOH(3) ILE(4) LEU(2) LYS(1) MTX(1) THR(3) ]	DIHYDROFOLATE REDUCTASE FROM THERMOTOGA MARITIMA DIHYDROFOLATE REDUCTASE OXIDOREDUCTASE DIMER, HYPERTHERMOPHILE, OXIDOREDUCTASE
1dls	prot     2.30	 AC1 [ ALA(1) ARG(2) ASP(1) GLU(2) GLY(4) HOH(7) ILE(1) LEU(1) LYS(2) MTX(1) SER(4) THR(2) TRP(1) TYR(1) VAL(3) ]	METHOTREXATE-RESISTANT VARIANTS OF HUMAN DIHYDROFOLATE REDUCTASE WITH SUBSTITUTION OF LEUCINE 22: KINETICS, CRYSTALLOGRAPHY AND POTENTIAL AS SELECTABLE MARKERS DIHYDROFOLATE REDUCTASE OXIDO-REDUCTASE OXIDO-REDUCTASE
1e7w	prot     1.75	 AC1 [ ALA(2) ARG(2) ASN(1) ASP(3) GLY(1) HIS(2) HOH(8) LEU(3) LYS(1) MET(1) MTX(1) PRO(1) SER(3) TYR(2) VAL(1) ]	ONE ACTIVE SITE, TWO MODES OF REDUCTION CORRELATE THE MECHANISM OF LEISHMANIA PTERIDINE REDUCTASE WITH PTERIN METABOLISM AND ANTIFOLATE DRUG RESISTANCE IN TRPANOSOMES PTERIDINE REDUCTASE OXIDOREDUCTASE DIHYDROFOLATE REDUCTASE, PTERIDINE REDUCTASE, SHORTCHAIN DEHYDROGENASE, METHOTREXATE RESISTANCE, OXIDOREDUCTASE
1mxf	prot     2.30	 AC1 [ ALA(1) ARG(3) ASN(1) ASP(1) CYS(1) GLU(1) GLY(2) HIS(1) HOH(3) ILE(1) LEU(3) LYS(1) MTX(1) PRO(1) SER(4) TYR(1) ]	CRYSTAL STRUCTURE OF INHIBITOR COMPLEX OF PUTATIVE PTERIDINE REDUCTASE 2 (PTR2) FROM TRYPANOSOMA CRUZI PTERIDINE REDUCTASE 2: PTERIDINE REDUCTASE OXIDOREDUCTASE SDR TOPOLOGY, PROTEIN-INHIBITOR COMPLEX, OXIDOREDUCTASE
1p33	prot     2.86	 AC1 [ ALA(2) ARG(2) ASN(1) ASP(3) GLY(2) HIS(1) HOH(3) LEU(3) LYS(1) MET(1) MTX(1) PRO(1) SER(5) TYR(1) VAL(1) ]	PTERIDINE REDUCTASE FROM LEISHMANIA TARENTOLAE COMPLEX WITH NADPH AND MTX PTERIDINE REDUCTASE 1: PTERIDINE REDUCTASE OXIDOREDUCTASE PTERIDINE REDUCTASE, COMPLEX, NADPH, CRYSTAL STRUCTURE, MTX, OXIDOREDUCTASE
1u72	prot     1.90	 AC1 [ ALA(1) ARG(2) ASP(1) GLU(1) GLY(4) HOH(2) ILE(1) LEU(2) LYS(2) MTX(1) SER(4) THR(2) TRP(1) TYR(1) VAL(3) ]	UNDERSTANDING THE ROLE OF LEU22 VARIANTS IN METHOTREXATE RESISTANCE: COMPARISON OF WILD-TYPE AND LEU22ARG VARIANT MOUSE AND HUMAN DIHYDRFOLATE REDUCTASE TERNARY CRYSTAL COMPLEXES WITH METHOTREXATE AND NADPH DIHYDROFOLATE REDUCTASE: HUMAN DHFR OXIDOREDUCTASE WILD TYPE HUMAND DHFR, OXIDOREDUCTASE
3cd2	prot     2.50	 AC1 [ ALA(2) ARG(3) ASN(1) GLN(1) GLY(3) HOH(1) ILE(3) LEU(2) LYS(2) MTX(1) SER(1) THR(2) TYR(1) ]	LIGAND INDUCED CONFORMATIONAL CHANGES IN THE CRYSTAL STRUCTURES OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE COMPLEXES WITH FOLATE AND NADP+ DIHYDROFOLATE REDUCTASE OXIDOREDUCTASE OXIDO-REDUCTASE, METHOTREXATE, NADPH, OXIDOREDUCTASE
3dfr	prot     1.70	 AC1 [ ALA(3) ARG(2) GLN(2) GLY(4) HIS(3) HOH(11) ILE(2) LEU(2) LYS(1) MTX(1) THR(2) TRP(1) ]	CRYSTAL STRUCTURES OF ESCHERICHIA COLI AND LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE REFINED AT 1.7 ANGSTROMS RESOLUTION. I. GENERAL FEATURES AND BINDING OF METHOTREXATE DIHYDROFOLATE REDUCTASE OXIDO-REDUCTASE OXIDO-REDUCTASE
3ia4	prot     1.70	 AC1 [ ALA(4) ARG(3) ASN(2) GLN(1) GLY(3) HOH(8) ILE(3) LEU(1) LYS(1) MTX(1) NDP(1) SER(1) THR(3) TYR(1) ]	MORITELLA PROFUNDA DIHYDROFOLATE REDUCTASE (DHFR) IN COMPLEX WITH NADPH AND METHOTREXATE (MTX) DIHYDROFOLATE REDUCTASE OXIDOREDUCTASE DHFR DIHYDROFOLATE REDUCTASE, NADPH, METHOTREXATE, OXIDOREDUCTASE
3ix9	prot     1.95	 AC1 [ ALA(1) ARG(3) ASN(1) GLN(1) GLY(4) HIS(1) HOH(10) ILE(2) LEU(2) LYS(1) MTX(1) THR(2) TRP(1) VAL(2) ]	CRYSTAL STRUCTURE OF STREPTOCOCCUS PNEUMONIAE DIHYDROFOLATE REDUCTASE - SP9 MUTANT DIHYDROFOLATE REDUCTASE OXIDOREDUCTASE CENTRAL BETA SHEET SURROUNDED BY 4 ALPHA HELICES, OXIDOREDUCTASE
3tq9	prot     2.30	 AC1 [ ALA(3) ARG(4) ASN(1) GLN(2) GLU(2) GLY(3) ILE(4) MTX(1) SER(1) THR(2) TYR(1) VAL(1) ]	STRUCTURE OF THE DIHYDROFOLATE REDUCTASE (FOLA) FROM COXIELL IN COMPLEX WITH METHOTREXATE DIHYDROFOLATE REDUCTASE OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIB COMPLEX
4ky8	prot     3.08	 AC1 [ ALA(1) ARG(2) CYS(1) GLN(1) GLU(1) GLY(4) ILE(2) LEU(1) LYS(1) MTX(1) SER(4) THR(2) ]	CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN WITH NADPH, METHOTREXATE, FDUMP AND 4-((2-AMINO-6-METHYL-4- DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)THIO)-2-CHLOROPHENY GLUTAMIC ACID BIFUNCTIONAL THYMIDYLATE SYNTHASE-DIHYDROFOLATE R CHAIN: A, B, C, D, E TRANSFERASE,OXIDOREDUCTASE/INHIBITOR BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERAS OXIDOREDUCTASE, TRANSFERASE,OXIDOREDUCTASE-INHIBITOR COMPLE
4q0d	prot     3.45	 AC1 [ ALA(1) ARG(2) CYS(1) GLN(1) GLU(1) GLY(5) ILE(2) LYS(1) MTX(1) SER(4) THR(2) ]	CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN WITH NADPH, FDUMP, METHOTREXATE AND 2-AMINO-4-OXO-4,7-DIHYD PYRROLO[2,3-D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID. BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE CHAIN: E, A, B, C, D TRANSFERASE/TRANSFERASE INHIBITOR BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERAS TRANSFERASE INHIBITOR COMPLEX
5x66	prot     1.99	 AC1 [ ARG(4) ASN(1) ASP(1) CYS(1) GLN(1) GLY(2) HIS(2) HOH(1) MTX(1) SER(1) TYR(1) ]	HUMAN THYMIDYLATE SYNTHASE IN COMPLEX WITH DUMP AND METHOTRE THYMIDYLATE SYNTHASE: UNP RESIDUES 26-313 TRANSFERASE METHYLTRANSFERASE, TRANSFERASE

AC2

Code	Class Resolution	Description
1df7	prot     1.70	 AC2 [ ALA(2) ARG(3) ASP(1) GLN(2) GLY(6) GOL(1) HOH(8) ILE(3) LEU(2) MTX(1) SER(1) THR(1) TRP(1) TYR(1) VAL(1) ]	DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLE NADPH AND METHOTREXATE DIHYDROFOLATE REDUCTASE OXIDOREDUCTASE DIHYDROFOLATE REDUCTASE, STRUCTURE-BASED INHIBITOR DESIGN, FOLATEANALOGS, ROSSMANN FOLD, NICOTINAMIDE ADENINE DINUCLEO METHOTREXATE, TUBERCULOSIS, OXIDOREDUCTASE
1dre	prot     2.60	 AC2 [ ALA(3) ARG(2) ASN(1) GLN(1) GLU(1) GLY(4) HIS(1) ILE(2) LEU(1) LYS(1) MET(1) MTX(1) SER(2) THR(1) TYR(1) VAL(1) ]	DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM) DIHYDROFOLATE REDUCTASE OXIDOREDUCTASE OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM
1p33	prot     2.86	 AC2 [ ALA(2) ARG(2) ASN(1) ASP(2) GLY(2) HIS(2) HOH(1) LEU(2) LYS(2) MET(1) MTX(1) PRO(1) SER(5) TYR(1) VAL(2) ]	PTERIDINE REDUCTASE FROM LEISHMANIA TARENTOLAE COMPLEX WITH NADPH AND MTX PTERIDINE REDUCTASE 1: PTERIDINE REDUCTASE OXIDOREDUCTASE PTERIDINE REDUCTASE, COMPLEX, NADPH, CRYSTAL STRUCTURE, MTX, OXIDOREDUCTASE
1rh3	prot     2.40	 AC2 [ ALA(3) ARG(2) ASN(1) GLN(1) GLY(3) HIS(1) ILE(2) LEU(1) LYS(1) MET(1) MTX(1) SER(2) THR(1) TYR(1) VAL(1) ]	DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (REDUCED FORM) DIHYDROFOLATE REDUCTASE OXIDOREDUCTASE OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM
1u70	prot     2.50	 AC2 [ ALA(1) ARG(2) ASP(1) GLU(2) GLY(4) LEU(1) LYS(2) MTX(1) SER(4) THR(1) TRP(1) TYR(1) VAL(3) ]	UNDERSTANDING THE ROLE OF LEU22 VARIANTS IN METHOTREXATE RESISTANCE: COMPARISON OF WILD-TYPE AND LEU22ARG VARIANT MOUSE AND HUMAN DIHYDROFOLATE REDUCTASE DIHYDROFOLATE REDUCTASE: MOUSE DHFR OXIDOREDUCTASE VARIANT DHFR MOUSE, HUMAN, OXIDOREDUCTASE
3dat	prot     2.30	 AC2 [ ALA(2) ARG(2) ASN(3) GLN(1) GLY(3) HIS(1) HOH(2) ILE(2) LEU(2) LYS(1) MTX(1) PHE(1) THR(2) TRP(1) TYR(1) VAL(2) ]	CRYSTAL STRUCTURE OF THE TERNARY MTX NADPH COMPLEX OF BACILL ANTHRACIS DIHYDROFOLATE REDUCTASE DIHYDROFOLATE REDUCTASE OXIDOREDUCTASE DUAL-SITE INHIBITION, OXIDOREDUCTASE, PSEUDO-ROSSMANN FOLD, NUCLEOTIDE BINDING DOMAIN
3dau	prot     1.50	 AC2 [ ALA(3) ARG(2) ASN(1) GLN(1) GLY(4) HIS(1) HOH(8) ILE(2) LEU(1) LYS(1) MET(2) MTX(1) SER(2) THR(1) TRP(1) TYR(1) VAL(1) ]	CRYSTAL STRUCTURE OF THE TERNARY MTX NADPH COMPLEX OF ESCHER DIHYDROFOLATE REDUCTASE DIHYDROFOLATE REDUCTASE OXIDOREDUCTASE OXIDOREDUCTASE, PSEUDO-ROSSMANN FOLD, ADENINE NUCLEOTIDE BIN DOMAIN, ANTIBIOTIC RESISTANCE, METHOTREXATE RESISTANCE, NAD CARBON METABOLISM, TRIMETHOPRIM RESISTANCE
4gh8	prot     1.85	 AC2 [ ALA(3) ARG(2) ASN(1) GLN(1) GLY(4) HIS(1) HOH(6) ILE(2) LEU(1) LYS(1) MTX(1) SER(2) THR(1) TYR(1) VAL(1) ]	CRYSTAL STRUCTURE OF A 'HUMANIZED' E. COLI DIHYDROFOLATE RED DIHYDROFOLATE REDUCTASE OXIDOREDUCTASE TETRAHYDROFOLATE, ENZYME CATALYSIS, EVOLUTION, DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE
4l8w	prot     2.39	 AC2 [ DGL(1) GLY(1) LYS(1) MTX(1) SER(1) ]	CRYSTAL STRUCTURE OF GAMMA GLUTAMYL HYDROLASE (H218N) FROM Z COMPLEX WITH MTX POLYGLUTAMATE GAMMA-GLUTAMYL HYDROLASE HYDROLASE SANDWICHED-LIKE DOMAIN, HYDROLASE
4p66	prot     1.84	 AC2 [ ALA(3) ARG(2) ASN(1) ASP(1) GLN(2) GLY(4) HIS(1) HOH(5) ILE(2) LEU(1) LYS(1) MET(1) MTX(1) SER(2) TYR(1) VAL(1) XCN(1) ]	ELECTROSTATICS OF ACTIVE SITE MICROENVIRONMENTS OF E. COLI D DIHYDROFOLATE REDUCTASE OXIDOREDUCTASE OXIDOREDUCTASE, CATALYSIS, ELECTROSTATICS, CATALYTIC CYCLE
4p68	prot     2.26	 AC2 [ ALA(3) ARG(2) ASN(1) ASP(1) GLN(2) GLU(1) GLY(3) HIS(1) HOH(3) ILE(2) LEU(1) LYS(1) MET(1) MTX(1) SER(2) THR(1) TYR(1) VAL(1) ]	ELECTROSTATICS OF ACTIVE SITE MICROENVIRONMENTS FOR E. COLI DIHYDROFOLATE REDUCTASE OXIDOREDUCTASE ELECTROSTATICS, CATALYSIS, OXIDOREDUCTASE, DHFR

AC3

Code	Class Resolution	Description
1axw	prot     1.70	 AC3 [ ARG(4) ASN(1) ASP(1) CYS(2) GLN(1) HIS(2) HOH(1) MTX(1) SER(1) TYR(1) ]	E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH METHOTREXATE (MTX) AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) THYMIDYLATE SYNTHASE METHYLTRANSFERASE METHYLTRANSFERASE, TRANSFERASE, INHIBITOR
1d1g	prot     2.10	 AC3 [ ALA(1) ARG(3) GLU(2) GLY(4) HOH(1) ILE(4) LEU(2) LYS(1) MTX(1) THR(3) ]	DIHYDROFOLATE REDUCTASE FROM THERMOTOGA MARITIMA DIHYDROFOLATE REDUCTASE OXIDOREDUCTASE DIMER, HYPERTHERMOPHILE, OXIDOREDUCTASE
1mxf	prot     2.30	 AC3 [ ALA(2) ARG(2) ASN(1) ASP(2) CYS(1) GLY(2) HIS(1) HOH(4) ILE(1) LEU(3) LYS(1) MTX(1) PRO(1) SER(4) TYR(2) ]	CRYSTAL STRUCTURE OF INHIBITOR COMPLEX OF PUTATIVE PTERIDINE REDUCTASE 2 (PTR2) FROM TRYPANOSOMA CRUZI PTERIDINE REDUCTASE 2: PTERIDINE REDUCTASE OXIDOREDUCTASE SDR TOPOLOGY, PROTEIN-INHIBITOR COMPLEX, OXIDOREDUCTASE
1p33	prot     2.86	 AC3 [ ALA(2) ARG(2) ASN(1) ASP(2) GLY(2) HIS(1) LEU(3) LYS(1) MET(1) MTX(1) PRO(1) SER(6) TYR(2) VAL(2) ]	PTERIDINE REDUCTASE FROM LEISHMANIA TARENTOLAE COMPLEX WITH NADPH AND MTX PTERIDINE REDUCTASE 1: PTERIDINE REDUCTASE OXIDOREDUCTASE PTERIDINE REDUCTASE, COMPLEX, NADPH, CRYSTAL STRUCTURE, MTX, OXIDOREDUCTASE
3ia4	prot     1.70	 AC3 [ ALA(4) ARG(3) ASN(2) GLN(1) GLY(3) HOH(6) ILE(3) LEU(2) LYS(1) MET(1) MTX(1) NDP(1) SER(2) THR(2) TRP(1) TYR(1) ]	MORITELLA PROFUNDA DIHYDROFOLATE REDUCTASE (DHFR) IN COMPLEX WITH NADPH AND METHOTREXATE (MTX) DIHYDROFOLATE REDUCTASE OXIDOREDUCTASE DHFR DIHYDROFOLATE REDUCTASE, NADPH, METHOTREXATE, OXIDOREDUCTASE
3ix9	prot     1.95	 AC3 [ ALA(1) ARG(3) ASN(2) GLN(1) GLY(4) HIS(1) HOH(10) ILE(2) LEU(2) LYS(2) MTX(1) THR(2) TRP(2) VAL(2) ]	CRYSTAL STRUCTURE OF STREPTOCOCCUS PNEUMONIAE DIHYDROFOLATE REDUCTASE - SP9 MUTANT DIHYDROFOLATE REDUCTASE OXIDOREDUCTASE CENTRAL BETA SHEET SURROUNDED BY 4 ALPHA HELICES, OXIDOREDUCTASE
4l8w	prot     2.39	 AC3 [ ALA(1) DGL(1) MTX(1) SER(1) ]	CRYSTAL STRUCTURE OF GAMMA GLUTAMYL HYDROLASE (H218N) FROM Z COMPLEX WITH MTX POLYGLUTAMATE GAMMA-GLUTAMYL HYDROLASE HYDROLASE SANDWICHED-LIKE DOMAIN, HYDROLASE
5x66	prot     1.99	 AC3 [ ARG(4) ASN(1) ASP(1) CYS(1) GLN(1) GLY(1) HIS(2) HOH(2) MTX(1) SER(1) TYR(1) ]	HUMAN THYMIDYLATE SYNTHASE IN COMPLEX WITH DUMP AND METHOTRE THYMIDYLATE SYNTHASE: UNP RESIDUES 26-313 TRANSFERASE METHYLTRANSFERASE, TRANSFERASE

AC4

Code	Class Resolution	Description
1df7	prot     1.70	 AC4 [ ASP(1) GLN(1) HOH(1) LEU(1) MTX(1) TRP(1) ]	DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLE NADPH AND METHOTREXATE DIHYDROFOLATE REDUCTASE OXIDOREDUCTASE DIHYDROFOLATE REDUCTASE, STRUCTURE-BASED INHIBITOR DESIGN, FOLATEANALOGS, ROSSMANN FOLD, NICOTINAMIDE ADENINE DINUCLEO METHOTREXATE, TUBERCULOSIS, OXIDOREDUCTASE
1e7w	prot     1.75	 AC4 [ ARG(1) ASP(1) HOH(3) MTX(1) PHE(1) TYR(1) ]	ONE ACTIVE SITE, TWO MODES OF REDUCTION CORRELATE THE MECHANISM OF LEISHMANIA PTERIDINE REDUCTASE WITH PTERIN METABOLISM AND ANTIFOLATE DRUG RESISTANCE IN TRPANOSOMES PTERIDINE REDUCTASE OXIDOREDUCTASE DIHYDROFOLATE REDUCTASE, PTERIDINE REDUCTASE, SHORTCHAIN DEHYDROGENASE, METHOTREXATE RESISTANCE, OXIDOREDUCTASE
1p33	prot     2.86	 AC4 [ ALA(2) ARG(2) ASN(1) ASP(1) GLY(2) HIS(1) HOH(1) LEU(2) LYS(1) MET(1) MTX(1) PRO(1) SER(5) TYR(1) VAL(2) ]	PTERIDINE REDUCTASE FROM LEISHMANIA TARENTOLAE COMPLEX WITH NADPH AND MTX PTERIDINE REDUCTASE 1: PTERIDINE REDUCTASE OXIDOREDUCTASE PTERIDINE REDUCTASE, COMPLEX, NADPH, CRYSTAL STRUCTURE, MTX, OXIDOREDUCTASE
1rx3	prot     2.20	 AC4 [ ALA(3) ARG(2) ASN(1) ASP(1) GLN(2) GLY(4) HIS(1) HOH(8) ILE(2) LEU(1) LYS(1) MET(2) MTX(1) SER(2) THR(1) TYR(1) VAL(1) ]	DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH METHOTREXATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (REDUCED FORM) DIHYDROFOLATE REDUCTASE OXIDOREDUCTASE OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM
3hj3	prot     2.70	 AC4 [ ALA(1) ARG(2) CYS(1) GLN(1) GLU(1) GLY(4) HOH(3) ILE(2) LEU(1) LYS(1) MTX(1) SER(4) THR(2) TYR(1) VAL(1) ]	CRYSTAL STRUCTURE OF THE CHTS-DHFR F207A NON-ACTIVE SITE MUT CHAIN A, CRYSTAL STRUCTURE OF DHFR OXIDOREDUCTASE TS, DHFR, ENZYME, CROSSOVER, NON-ACTIVE SITE, OXIDOREDUCTASE

AC5

Code	Class Resolution	Description
1e7w	prot     1.75	 AC5 [ ALA(2) ARG(2) ASN(1) ASP(3) GLY(1) HIS(2) HOH(8) LEU(2) LYS(1) MET(1) MTX(1) PRO(1) SER(3) TYR(2) VAL(1) ]	ONE ACTIVE SITE, TWO MODES OF REDUCTION CORRELATE THE MECHANISM OF LEISHMANIA PTERIDINE REDUCTASE WITH PTERIN METABOLISM AND ANTIFOLATE DRUG RESISTANCE IN TRPANOSOMES PTERIDINE REDUCTASE OXIDOREDUCTASE DIHYDROFOLATE REDUCTASE, PTERIDINE REDUCTASE, SHORTCHAIN DEHYDROGENASE, METHOTREXATE RESISTANCE, OXIDOREDUCTASE
1mxf	prot     2.30	 AC5 [ ALA(1) ARG(3) ASN(1) ASP(1) CYS(1) GLY(2) HIS(1) HOH(6) ILE(1) LEU(3) LYS(1) MTX(1) PRO(1) SER(4) TYR(1) ]	CRYSTAL STRUCTURE OF INHIBITOR COMPLEX OF PUTATIVE PTERIDINE REDUCTASE 2 (PTR2) FROM TRYPANOSOMA CRUZI PTERIDINE REDUCTASE 2: PTERIDINE REDUCTASE OXIDOREDUCTASE SDR TOPOLOGY, PROTEIN-INHIBITOR COMPLEX, OXIDOREDUCTASE
2c7v	prot     2.20	 AC5 [ ALA(2) ARG(1) ASN(2) ASP(1) CYS(1) GLY(1) HIS(1) HOH(10) ILE(1) LEU(3) LYS(1) MTX(1) PRO(1) SER(3) THR(2) TYR(2) ]	STRUCTURE OF TRYPANOSOMA BRUCEI PTERIDINE REDUCTASE (PTR1) IN TERNARY COMPLEX WITH COFACTOR AND THE ANTIFOLATE METHOTREXATE PTERIDINE REDUCTASE OXIDOREDUCTASE PTERIDINE REDUCTASE, TRYPANOSOMATIDS, DRUG RESISTANCE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE, METHOTREXATE RESISTANCE, OXIDOREDUCTASE
3ia4	prot     1.70	 AC5 [ ALA(4) ARG(3) ASN(2) GLN(1) GLY(3) HOH(7) ILE(3) LEU(1) LYS(1) MET(1) MTX(1) NDP(1) SER(2) THR(3) TYR(1) ]	MORITELLA PROFUNDA DIHYDROFOLATE REDUCTASE (DHFR) IN COMPLEX WITH NADPH AND METHOTREXATE (MTX) DIHYDROFOLATE REDUCTASE OXIDOREDUCTASE DHFR DIHYDROFOLATE REDUCTASE, NADPH, METHOTREXATE, OXIDOREDUCTASE
4gh8	prot     1.85	 AC5 [ ALA(3) ARG(2) ASN(1) GLN(1) GLY(4) HIS(1) HOH(7) ILE(2) LEU(1) LYS(1) MTX(1) SER(2) THR(1) TYR(1) VAL(1) ]	CRYSTAL STRUCTURE OF A 'HUMANIZED' E. COLI DIHYDROFOLATE RED DIHYDROFOLATE REDUCTASE OXIDOREDUCTASE TETRAHYDROFOLATE, ENZYME CATALYSIS, EVOLUTION, DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE
4ky8	prot     3.08	 AC5 [ ALA(1) ARG(2) CYS(1) GLN(1) GLU(1) GLY(4) ILE(2) LEU(1) LYS(1) MTX(1) SER(4) THR(2) ]	CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN WITH NADPH, METHOTREXATE, FDUMP AND 4-((2-AMINO-6-METHYL-4- DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)THIO)-2-CHLOROPHENY GLUTAMIC ACID BIFUNCTIONAL THYMIDYLATE SYNTHASE-DIHYDROFOLATE R CHAIN: A, B, C, D, E TRANSFERASE,OXIDOREDUCTASE/INHIBITOR BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERAS OXIDOREDUCTASE, TRANSFERASE,OXIDOREDUCTASE-INHIBITOR COMPLE
4l8w	prot     2.39	 AC5 [ ASN(1) DGL(1) GLY(1) LYS(1) MTX(1) SER(1) ]	CRYSTAL STRUCTURE OF GAMMA GLUTAMYL HYDROLASE (H218N) FROM Z COMPLEX WITH MTX POLYGLUTAMATE GAMMA-GLUTAMYL HYDROLASE HYDROLASE SANDWICHED-LIKE DOMAIN, HYDROLASE
4q0d	prot     3.45	 AC5 [ ALA(1) ARG(2) CYS(1) GLN(1) GLU(1) GLY(4) ILE(2) LYS(1) MTX(1) SER(5) THR(2) ]	CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN WITH NADPH, FDUMP, METHOTREXATE AND 2-AMINO-4-OXO-4,7-DIHYD PYRROLO[2,3-D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID. BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE CHAIN: E, A, B, C, D TRANSFERASE/TRANSFERASE INHIBITOR BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERAS TRANSFERASE INHIBITOR COMPLEX
5x66	prot     1.99	 AC5 [ ARG(2) ASN(1) ASP(1) CYS(1) GLN(1) GLY(2) HIS(2) HOH(2) MTX(1) SER(1) TYR(1) ]	HUMAN THYMIDYLATE SYNTHASE IN COMPLEX WITH DUMP AND METHOTRE THYMIDYLATE SYNTHASE: UNP RESIDUES 26-313 TRANSFERASE METHYLTRANSFERASE, TRANSFERASE

AC6

Code	Class Resolution	Description
1drb	prot     1.96	 AC6 [ CYS(1) MTX(1) ]	CRYSTAL STRUCTURE OF UNLIGANDED ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. LIGAND-INDUCED CONFORMATIONAL CHANGES AND COOPERATIVITY IN BINDING DIHYDROFOLATE REDUCTASE OXIDOREDUCTASE OXIDOREDUCTASE
4l8w	prot     2.39	 AC6 [ ALA(1) DGL(1) HOH(1) MTX(1) PHE(1) SER(1) TYR(1) ]	CRYSTAL STRUCTURE OF GAMMA GLUTAMYL HYDROLASE (H218N) FROM Z COMPLEX WITH MTX POLYGLUTAMATE GAMMA-GLUTAMYL HYDROLASE HYDROLASE SANDWICHED-LIKE DOMAIN, HYDROLASE

AC7

Code	Class Resolution	Description
1drb	prot     1.96	 AC7 [ ALA(1) CYS(1) MTX(1) ]	CRYSTAL STRUCTURE OF UNLIGANDED ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. LIGAND-INDUCED CONFORMATIONAL CHANGES AND COOPERATIVITY IN BINDING DIHYDROFOLATE REDUCTASE OXIDOREDUCTASE OXIDOREDUCTASE
1e7w	prot     1.75	 AC7 [ ARG(1) ASP(1) HOH(2) MTX(1) ]	ONE ACTIVE SITE, TWO MODES OF REDUCTION CORRELATE THE MECHANISM OF LEISHMANIA PTERIDINE REDUCTASE WITH PTERIN METABOLISM AND ANTIFOLATE DRUG RESISTANCE IN TRPANOSOMES PTERIDINE REDUCTASE OXIDOREDUCTASE DIHYDROFOLATE REDUCTASE, PTERIDINE REDUCTASE, SHORTCHAIN DEHYDROGENASE, METHOTREXATE RESISTANCE, OXIDOREDUCTASE
1mxf	prot     2.30	 AC7 [ ALA(1) ARG(3) ASN(1) ASP(1) CYS(1) GLU(1) GLY(2) HIS(1) HOH(7) ILE(1) LEU(3) LYS(1) MTX(1) PRO(1) SER(4) TYR(2) ]	CRYSTAL STRUCTURE OF INHIBITOR COMPLEX OF PUTATIVE PTERIDINE REDUCTASE 2 (PTR2) FROM TRYPANOSOMA CRUZI PTERIDINE REDUCTASE 2: PTERIDINE REDUCTASE OXIDOREDUCTASE SDR TOPOLOGY, PROTEIN-INHIBITOR COMPLEX, OXIDOREDUCTASE
2c7v	prot     2.20	 AC7 [ ALA(2) ARG(1) ASN(2) ASP(1) CYS(1) GLY(1) HIS(2) HOH(8) ILE(1) LEU(3) LYS(1) MTX(1) PRO(1) SER(3) THR(2) TYR(2) ]	STRUCTURE OF TRYPANOSOMA BRUCEI PTERIDINE REDUCTASE (PTR1) IN TERNARY COMPLEX WITH COFACTOR AND THE ANTIFOLATE METHOTREXATE PTERIDINE REDUCTASE OXIDOREDUCTASE PTERIDINE REDUCTASE, TRYPANOSOMATIDS, DRUG RESISTANCE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE, METHOTREXATE RESISTANCE, OXIDOREDUCTASE
3ia4	prot     1.70	 AC7 [ ALA(4) ARG(3) ASN(2) GLN(1) GLY(3) HOH(6) ILE(3) LEU(2) LYS(1) MET(1) MTX(1) NDP(1) SER(2) THR(2) TYR(1) ]	MORITELLA PROFUNDA DIHYDROFOLATE REDUCTASE (DHFR) IN COMPLEX WITH NADPH AND METHOTREXATE (MTX) DIHYDROFOLATE REDUCTASE OXIDOREDUCTASE DHFR DIHYDROFOLATE REDUCTASE, NADPH, METHOTREXATE, OXIDOREDUCTASE
5x66	prot     1.99	 AC7 [ ARG(4) ASN(1) ASP(1) CYS(1) GLN(1) GLY(1) HIS(2) HOH(3) MTX(1) SER(1) TYR(1) ]	HUMAN THYMIDYLATE SYNTHASE IN COMPLEX WITH DUMP AND METHOTRE THYMIDYLATE SYNTHASE: UNP RESIDUES 26-313 TRANSFERASE METHYLTRANSFERASE, TRANSFERASE

AC8

Code	Class Resolution	Description
3hj3	prot     2.70	 AC8 [ ALA(1) ARG(2) CYS(1) GLN(1) GLU(1) GLY(4) HOH(2) ILE(3) LEU(1) LYS(1) MTX(1) SER(5) THR(2) ]	CRYSTAL STRUCTURE OF THE CHTS-DHFR F207A NON-ACTIVE SITE MUT CHAIN A, CRYSTAL STRUCTURE OF DHFR OXIDOREDUCTASE TS, DHFR, ENZYME, CROSSOVER, NON-ACTIVE SITE, OXIDOREDUCTASE

AC9

Code	Class Resolution	Description
2c7v	prot     2.20	 AC9 [ ALA(2) ARG(1) ASN(2) ASP(1) CYS(1) GLY(1) HIS(1) HOH(7) ILE(1) LEU(3) LYS(1) MTX(1) PRO(1) SER(3) THR(2) TYR(2) VAL(1) ]	STRUCTURE OF TRYPANOSOMA BRUCEI PTERIDINE REDUCTASE (PTR1) IN TERNARY COMPLEX WITH COFACTOR AND THE ANTIFOLATE METHOTREXATE PTERIDINE REDUCTASE OXIDOREDUCTASE PTERIDINE REDUCTASE, TRYPANOSOMATIDS, DRUG RESISTANCE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE, METHOTREXATE RESISTANCE, OXIDOREDUCTASE
4ky8	prot     3.08	 AC9 [ ALA(1) ARG(2) CYS(1) GLN(1) GLU(1) GLY(4) ILE(2) LEU(1) LYS(1) MTX(1) SER(4) THR(2) VAL(1) ]	CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN WITH NADPH, METHOTREXATE, FDUMP AND 4-((2-AMINO-6-METHYL-4- DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)THIO)-2-CHLOROPHENY GLUTAMIC ACID BIFUNCTIONAL THYMIDYLATE SYNTHASE-DIHYDROFOLATE R CHAIN: A, B, C, D, E TRANSFERASE,OXIDOREDUCTASE/INHIBITOR BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERAS OXIDOREDUCTASE, TRANSFERASE,OXIDOREDUCTASE-INHIBITOR COMPLE
4q0d	prot     3.45	 AC9 [ ALA(1) ARG(2) CYS(1) GLN(1) GLU(1) GLY(4) ILE(2) LYS(1) MTX(1) SER(4) THR(2) VAL(1) ]	CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN WITH NADPH, FDUMP, METHOTREXATE AND 2-AMINO-4-OXO-4,7-DIHYD PYRROLO[2,3-D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID. BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE CHAIN: E, A, B, C, D TRANSFERASE/TRANSFERASE INHIBITOR BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERAS TRANSFERASE INHIBITOR COMPLEX
5x66	prot     1.99	 AC9 [ ARG(3) ASN(1) ASP(1) CYS(1) GLN(1) GLY(2) HIS(2) HOH(2) MTX(1) SER(1) TYR(1) ]	HUMAN THYMIDYLATE SYNTHASE IN COMPLEX WITH DUMP AND METHOTRE THYMIDYLATE SYNTHASE: UNP RESIDUES 26-313 TRANSFERASE METHYLTRANSFERASE, TRANSFERASE

AD2

Code	Class Resolution	Description
5x66	prot     1.99	 AD2 [ ARG(2) ASN(1) ASP(1) CYS(1) GLN(1) GLY(1) HIS(2) HOH(2) MTX(1) SER(1) TYR(1) ]	HUMAN THYMIDYLATE SYNTHASE IN COMPLEX WITH DUMP AND METHOTRE THYMIDYLATE SYNTHASE: UNP RESIDUES 26-313 TRANSFERASE METHYLTRANSFERASE, TRANSFERASE

BC2

Code	Class Resolution	Description
2c7v	prot     2.20	 BC2 [ ALA(2) ARG(1) ASN(2) ASP(1) CYS(1) GLY(1) HIS(2) HOH(8) ILE(1) LEU(2) LYS(1) MTX(1) PRO(1) SER(3) THR(2) TYR(2) ]	STRUCTURE OF TRYPANOSOMA BRUCEI PTERIDINE REDUCTASE (PTR1) IN TERNARY COMPLEX WITH COFACTOR AND THE ANTIFOLATE METHOTREXATE PTERIDINE REDUCTASE OXIDOREDUCTASE PTERIDINE REDUCTASE, TRYPANOSOMATIDS, DRUG RESISTANCE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE, METHOTREXATE RESISTANCE, OXIDOREDUCTASE

BC3

Code	Class Resolution	Description
3hj3	prot     2.70	 BC3 [ ALA(1) ARG(2) CYS(1) GLN(1) GLU(1) GLY(5) HOH(2) ILE(4) LEU(1) LYS(1) MTX(1) SER(3) THR(2) ]	CRYSTAL STRUCTURE OF THE CHTS-DHFR F207A NON-ACTIVE SITE MUT CHAIN A, CRYSTAL STRUCTURE OF DHFR OXIDOREDUCTASE TS, DHFR, ENZYME, CROSSOVER, NON-ACTIVE SITE, OXIDOREDUCTASE

BC4

Code	Class Resolution	Description
4ky8	prot     3.08	 BC4 [ ALA(1) ARG(2) CYS(1) GLN(1) GLU(1) GLY(4) ILE(3) LEU(1) LYS(1) MTX(1) SER(4) THR(2) ]	CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN WITH NADPH, METHOTREXATE, FDUMP AND 4-((2-AMINO-6-METHYL-4- DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)THIO)-2-CHLOROPHENY GLUTAMIC ACID BIFUNCTIONAL THYMIDYLATE SYNTHASE-DIHYDROFOLATE R CHAIN: A, B, C, D, E TRANSFERASE,OXIDOREDUCTASE/INHIBITOR BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERAS OXIDOREDUCTASE, TRANSFERASE,OXIDOREDUCTASE-INHIBITOR COMPLE
4q0d	prot     3.45	 BC4 [ ALA(1) ARG(2) CYS(1) GLN(1) GLU(1) GLY(4) ILE(3) LYS(1) MTX(1) SER(5) THR(2) ]	CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN WITH NADPH, FDUMP, METHOTREXATE AND 2-AMINO-4-OXO-4,7-DIHYD PYRROLO[2,3-D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID. BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE CHAIN: E, A, B, C, D TRANSFERASE/TRANSFERASE INHIBITOR BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERAS TRANSFERASE INHIBITOR COMPLEX

BC5

Code	Class Resolution	Description
3hj3	prot     2.70	 BC5 [ ALA(1) ARG(2) ASN(1) CYS(1) GLN(1) GLU(1) GLY(3) ILE(3) LYS(1) MTX(1) SER(3) THR(2) ]	CRYSTAL STRUCTURE OF THE CHTS-DHFR F207A NON-ACTIVE SITE MUT CHAIN A, CRYSTAL STRUCTURE OF DHFR OXIDOREDUCTASE TS, DHFR, ENZYME, CROSSOVER, NON-ACTIVE SITE, OXIDOREDUCTASE

BC8

Code	Class Resolution	Description
4ky8	prot     3.08	 BC8 [ ALA(1) ARG(2) CYS(1) GLN(1) GLU(1) GLY(4) ILE(2) LEU(1) LYS(1) MTX(1) SER(4) THR(2) ]	CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN WITH NADPH, METHOTREXATE, FDUMP AND 4-((2-AMINO-6-METHYL-4- DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)THIO)-2-CHLOROPHENY GLUTAMIC ACID BIFUNCTIONAL THYMIDYLATE SYNTHASE-DIHYDROFOLATE R CHAIN: A, B, C, D, E TRANSFERASE,OXIDOREDUCTASE/INHIBITOR BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERAS OXIDOREDUCTASE, TRANSFERASE,OXIDOREDUCTASE-INHIBITOR COMPLE
4q0d	prot     3.45	 BC8 [ ALA(1) ARG(2) CYS(1) GLN(1) GLU(1) GLY(4) ILE(2) LYS(1) MTX(1) SER(4) THR(2) ]	CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN WITH NADPH, FDUMP, METHOTREXATE AND 2-AMINO-4-OXO-4,7-DIHYD PYRROLO[2,3-D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID. BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE CHAIN: E, A, B, C, D TRANSFERASE/TRANSFERASE INHIBITOR BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERAS TRANSFERASE INHIBITOR COMPLEX

NND

Code	Class Resolution	Description
3dfr	prot     1.70	 NND [ ALA(2) GLY(2) HOH(1) ILE(1) LEU(1) MTX(1) PHE(1) THR(1) TRP(2) ]	CRYSTAL STRUCTURES OF ESCHERICHIA COLI AND LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE REFINED AT 1.7 ANGSTROMS RESOLUTION. I. GENERAL FEATURES AND BINDING OF METHOTREXATE DIHYDROFOLATE REDUCTASE OXIDO-REDUCTASE OXIDO-REDUCTASE

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