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(-) Description

Title :  CRYSTAL STRUCTURE OF THE HUMAN 8-OXOGUANINE GLYCOSYLASE (OGG1) PROCESSED WITH THE CRYSTALDIRECT AUTOMATED MOUNTING AND CRYO-COOLING TECHNOLOGY
 
Authors :  U. Zander, M. Ytre-Arne, B. Dalhus, G. Hoffmann, I. Cornaciu, F. Cipria J. A. Marquez
Date :  04 Sep 15  (Deposition) - 13 Apr 16  (Release) - 20 Apr 16  (Revision)
Method :  X-RAY DIFFRACTION
Resolution :  1.60
Chains :  Asym. Unit :  A
Biol. Unit 1:  A  (1x)
Keywords :  Hydrolase, Allergen, Pyr/Pyl/Rcar, Bet V 1, Flavonoids, Automated Crystal Harvesting, Automated Cryo-Cooling, Crystaldirect (Keyword Search: [Gene Ontology, PubMed, Web (Google)] )
 
Reference :  U. Zander, G. Hoffmann, I. Cornaciu, J. -P. Marquette, G. Papp, C. Landret, G. Seroul, J. Sinoir, M. Roewer, F. Felisaz, S. Rodriguez-Puente, V. Mariaule, P. Murphy, M. Mathieu, F. Cipriani J. A. Marquez
Automated Harvesting And Processing Of Protein Crystals Through Laser Photoablation.
Acta Crystallogr. , Sect. D V. 72 454 2016
PubMed-ID: 27050125  |  Reference-DOI: 10.1107/S2059798316000954

(-) Compounds

Molecule 1 - N-GLYCOSYLASE/DNA LYASE
    Chains: A
    EC Number: 3.2.2.23, 4.2.99.18
    Engineered: YES
    Expression System: ESCHERICHIA COLI
    Expression System Taxid: 562
    Fragment: UNP RESIDUES 12-323
    Organism Common: HUMAN
    Organism Scientific: HOMO SAPIENS
    Organism Taxid: 9606
    Synonym: 8-OXOGUANINE DNA GLYCOSYLASE

 Structural Features

(-) Chains, Units

  1
Asymmetric Unit : A
Biological Unit 1 (1x): A

Summary Information (see also Sequences/Alignments below)

(-) Ligands, Modified Residues, Ions  (1, 2)

Asymmetric Unit (1, 2)
No.NameCountTypeFull Name
1SO42Ligand/IonSULFATE ION
Biological Unit 1 (1, 2)
No.NameCountTypeFull Name
1SO42Ligand/IonSULFATE ION

(-) Sites  (2, 2)

Asymmetric Unit (2, 2)
No.NameEvidenceResiduesDescription
1AC1SOFTWARETHR A:69 , GLU A:70 , GLU A:71 , GLN A:72 , GLY A:308 , PRO A:309 , HOH A:640 , HOH A:680BINDING SITE FOR RESIDUE SO4 A 400
2AC2SOFTWAREPRO A:20 , TRP A:23 , ALA A:24 , HIS A:74 , PHE A:302 , SER A:305 , LEU A:306BINDING SITE FOR RESIDUE SO4 A 600

(-) SS Bonds  (0, 0)

(no "SS Bond" information available for 5AN4)

(-) Cis Peptide Bonds  (0, 0)

(no "Cis Peptide Bond" information available for 5AN4)

 Sequence-Structure Mapping

(-) SAPs(SNPs)/Variants  (0, 0)

(no "SAP(SNP)/Variant" information available for 5AN4)

(-) PROSITE Motifs  (0, 0)

(no "PROSITE Motif" information available for 5AN4)

(-) Exons   (0, 0)

(no "Exon" information available for 5AN4)

(-) Sequences/Alignments

Asymmetric Unit
   Reformat: Number of residues per line =  ('0' or empty: single-line sequence representation)
  Number of residues per labelling interval =   
  UniProt sequence: complete  aligned part    
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SAPs(SNPs) PROSITE motifs Exons
(details for a mapped element are shown in a popup box when the mouse pointer rests over it) 
Chain A from PDB  Type:PROTEIN  Length:312
                                                                                                                                                                                                                                                                                                                                                        
               SCOP domains ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ SCOP domains
               CATH domains ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ CATH domains
               Pfam domains ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ Pfam domains
         Sec.struct. author .......hhhhheeee......hhhhhh.......eeeee..eeeee....eeeeee...eeeeee.hhhhh.....hhhhhhhhhhhh....hhhhhhhhhhhhhhhhhhhhhhh........hhhhhhhhhhh....hhhhhhhhhhhhhhhhh.eeeee..eeee...hhhhhh..hhhhhhhhh...hhhhhhhhhhhhhhhhh.hhhhhhhhhhhhhhhhhhhhhh....hhhhhhhhhhhhh........hhhhhhhhhhhhh...........hhhhhhhhhhhhhhhhh.hhhhhhhhhhhhhh Sec.struct. author
                 SAPs(SNPs) ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ SAPs(SNPs)
                    PROSITE ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ PROSITE
                 Transcript ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ Transcript
                 5an4 A  12 GHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLADQVWTLTQTEEQLHCTVYRGDKSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHFQEVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHGFPSLQALAGPEVEAHLRKLGLGYRARYVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTKVADCICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQTNKELGNFFRSLWGPYAGWAQAVLFSADL 323
                                    21        31        41        51        61        71        81        91       101       111       121       131       141       151       161       171       181       191       201       211       221       231       241       251       261       271       281       291       301       311       321
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 Classification and Annotation

(-) SCOP Domains  (0, 0)

(no "SCOP Domain" information available for 5AN4)

(-) CATH Domains  (0, 0)

(no "CATH Domain" information available for 5AN4)

(-) Pfam Domains  (0, 0)

(no "Pfam Domain" information available for 5AN4)

(-) Gene Ontology  (42, 42)

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  5an4
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  OGG1_HUMAN | O15527
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  3.2.2.23
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  4.2.99.18
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 Related Entries

(-) Entries Sharing at Least One Protein Chain (UniProt ID)

UniProtKB/Swiss-Prot
        OGG1_HUMAN | O15527: 1ebm 1fn7 1hu0 1ko9 1lwv 1lww 1lwy 1m3h 1m3q 1n39 1n3a 1n3c 1yqk 1yql 1yqm 1yqr 2i5w 2nob 2noe 2nof 2noh 2noi 2nol 2noz 2xhi 3ih7 3ktu

(-) Related Entries Specified in the PDB File

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